UFC 331: Van vs. Pantoja 2 was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on September 19, 2026, at Crypto.com Arena in Los Angeles, California, United States. A UFC Flyweight Championship rematch between current champion Joshua Van and former champion Alexandre Pantoja headlined the event. They previously competed in December 2025 at UFC 323, where Van won the belt via technical knockout 26 seconds into the first round as a result of an arm injury sustained by Pantoja.